Posts Tagged ‘immunohistochemistry’

Understanding Pathology Reports

Question: Please check my pathology results and advise me how I should proceed. Hope to hear from you at your earliest convenience. Thanks

Understanding Pathology Report

Question: Understanding my report: invasive ductal carcinoma -histologic grade: nottingham histologic score III/III (tubule score=3, nuclear score=3, mitoses=2) -size of largest focus: 09 cm Estrogen receptor-negative (0%) Progesterone receptor-negative (0%) HER2/neu-positive (3%) Ki

Is Bilateral Mastectomy Necessary When Another Cancer Shows up in the Opposite Breast?

Question: I had a needle core biopsy LEFT breast…under Diagnosis it states …….-invasive mammary carcinoma (crush artifact present)……diagnosis confirmation by the Dr on april 1st 2013 Speciman that was sent was labelled “core biopsy left breast” and consisted of 3 cores of tan yellow core biopsies measuring from .3cm to .6 cm…….with one needle core [...]

What Do You Know About The Doctor That Diagnosed Your Breast Biopsy?

If you or someone you know has felt a breast lump or had an abnormal mammogram, you know it can be a very scary situation.  The immediate fear is “I might have breast cancer.” When confronted with a breast health issue, many patients seek out a particular breast center or a breast doctor well-known for [...]

Understanding Pathology Reports

Question: i had a needle core biopsy and this is what the pathology said but i do not understand right breast -invasive mammary carcinoma -no lymphovascular or ductal carcinoma in situ identified –breast cancer prognosis profile –estrogen recptor 100% positivity(favorable) –progesterone rector 100% positivity(favorable) –ki-67-30% postivity(elevated, unfavorable) –her2 cen-17 ratio pending can you help me [...]

High Grade DCIS

Question: I would like to understand better this Final Diagnosis:left breast, retroareolar,stereotactic core biopsy: Ductal carcinoma in-situ,high nuclear,cribriform,solid and comedo types. Ductal carcinoma in situ is associated with calcifications and necrosis. Note:Immunostains for strogen receptor and progesterone receptor will be performed and reported in an addendum. ADDENDUM:ductal carcinoma in-situ is strongly and diffusely positive for [...]

Tubular Carcinoma

Question: Hello: I am a 50 year old premenopausal female. I had a 2.5 mm tubular carcinoma diagnosed in Dec 2010 and had a simple mastectomy and neg SNB. I then had a prophylactic mastectomy in March of the other side. There were atypical hyperplastic lobular and ductal cell changes in the remainder of my [...]

Invasive Lobular vs. Invasive Ductal Carcinoma

Question: What is the difference between invasive lobular and ductal carcinoma? My first biopsy I had at my ultrasound said “invasive lobular carcinoma grade 2/3″ and my surgery biopsy said “invasive ductal carcinoma grade 2/3″. Does this make any difference?

Second Opinion Pathology Talk

I recently gave a talk on second opinions in breast pathology at the 21st Annual Conference of the National Consortium of Breast Centers in Las Vegas. A modified version of that talk is available here as a pdf: Second_Opinion_Pathology The first part of the talk covers some of the data in the literature and the [...]

Prognostic Marker Changes in Metastatic Breast Cancer

There is a recent study published in the September 23 issue of Breast Cancer Research that looked at changes in prognostic markers (estrogen/progesterone receptor and HER2/neu) between primary breast cancers and metastatic lesions. If you click on the Breast Cancer Research link it will provide you with the abstract.  The full article is temporarily free from [...]