High Grade DCIS

Question: I would like to understand better this Final Diagnosis:left breast, retroareolar,stereotactic core biopsy:
Ductal carcinoma in-situ,high nuclear,cribriform,solid and comedo types.
Ductal carcinoma in situ is associated with calcifications and necrosis.
Note:Immunostains for strogen receptor and progesterone receptor will be performed and reported in an addendum.
ADDENDUM:ductal carcinoma in-situ is strongly and diffusely positive for strogen and progesterone receptor (over 90% of cells). How agressive is this?? Please give us your best information and your best advise. God bless you.

Answer: It looks like this was just a core biopsy and so you unfortunately will need to have further surgery, either a lumpectomy or a mastectomy. This will depend on whether your doctors (surgeon and breast imager) feel the area of concern is amenable to a lumpectomy or if a mastectomy is needed. Ductal carcinoma in situ (DCIS) is graded from 1-3 (low, intermediate, high) and whether or not there is necrosis. You seem to have been diagnosed with high grade DCIS with necrosis and so your doctors might recommend a sentinel lymph node biopsy at time of surgery. So far you are not diagnosed with invasive breast cancer and hopefully there will be no invasion at time of surgery. It is good news that the DCIS is ER and PR strongly positive! Further recommendations are hard to predict until you know the Pathology results after your definitive surgery. Best wishes to you.

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